The first section of the thesis covers general information about the tropical disease Malaria. It includes an introduction, followed by a description of the human pathogenic parasites, their life cycle, different types of Malaria caused by individual parasites, and the symptoms after being infected. Furthermore, diagnostic methods, preventive and therapeutic measures including antimalarial drugs are listed. Moreover, it deals with the issue of drug resistance and various ways of designing new antimalarial agents for the future. The main focus of interest, which is described in the theoretical section, revolved around the synthesis of novel 4-Aminoquinoline derivatives. The most important past representative of these antimalarial-effective 4-Aminoquinolines used to be Chloroquine. As a result of the progressively developing drug resistance in Plasmodium falciparum strains, the need for new antimalarial agents as well as derivatives has grown rapidly. Another emphasis was put on linking two antimalarial agents to form so-called hybrid molecules. According to recent data, azabicyclononane- and bicyclooctane-derivatives showed promising antimalarial effects. Therefore, these two novel derivatives should be used for synthesizing hybrids with 4-Aminoquinolines. The experimental section contains information about the methods, instruments and materials applied as well as the detailed synthesis directives of all newly gained substances. All final substances were characterized by NMR-spectrometry, and their anti-plasmodial effect and cytotoxicity will be tested at the Swiss Tropical and Public Health Institute in Basel.