Theory: The increasing availability of high calorie food cues encourages unhealthy eating behaviour and overweight. Concerning normal-weights (NW), it has already been shown that the subjective and neural processing of visual food cues can be modified by a bitter taste. In this context, the aim of this study was to investigate possible differences compared to overweight (OW) people and to explore whether the above mentioned processing mechanisms are influenced by individual differences in sensitivity to reward and punishment (BAS, BIS). Method: The sample consisted of 37 NW and 37 OW women, each participating in two fMRI measurements. Each time before entering the scanner, they were asked to rinse their mouth with a fluid once containing a neutral (water) and once a bitter taste (wormwood tea). This was followed by a presentation of 30 pictures of vegetables and 30 pictures of sweets, which were rated regarding valence, arousal and appetite. BIS/BAS-scores were gathered via online survey. Results: NW and OW did not differ in their food cue ratings. However, comparing tea to water, OW showed weaker activation in fr. operculum, hippocampus, amygdala, n. accumbens and pallidum. In addition, NW BAS-scores correlated negatively (tendencially) with activation of the fr. operculum, OW BIS-scores correlated positively with activation in insula, n. accumbens and pallidum. Conclusions: This study provides evidence that, compared to NW, OW have deficits in the integration of multisensory stimuli, as the induction of a bitter taste had no effect on brain activation when viewing the sweets. However, it has been shown that individual BIS/BAS-scores are important. Regarding OW women, increased BIS-values result in a more intense perception of the incongruent stimuli. In contrast, more reward-sensitive NW showed tendencies of crossmodal-integrative deficits.