The analysis of religion in video games as a field of research has only gained momentum within the scientific community in recent years. Thus said, games represent the same mediatizations of postmodern religion as already been shown by films and TV series.BIOSHOCK INFINITE (Developer: Irrational Games, USA 2013), the main focal point of this masters thesis, represents a certain kind of Protestant fundamentalism which has been superimposed with American thinking and other religious ideas and movements. This new and syncretistic religion not only draws inspiration from Protestantism but also particularly from the political sphere. Nevertheless, the most central aspects of the religion in BIOSHOCK INFINITE derive from the Protestant fundamentalism in its prime at the dawn of the 20th century. Therefore, the transformation of these elements within the game should be analyzed and discussed on the basis of the US-American religious history and cultural history.As the analysis has shown, the game establishes a complex religious construct, a composition of American and Protestant tradition, which evolves to an extremist, racist as well as dystopian religious system, lead by a charismatic leader. The game's criticism of this politicized religious system refers mostly to sociocultural and political conflicts that derive from it, rendering it negative. The compound of politics, religion and Americanism as a charismatic, theocratic religious system is the main focus in the discussion about the transformation of religiosity in BIOSHOCK INFINITE and shows how games mediatize religion. Thus said, the raised discourse and critic refers not to religion per se, but to an exaggerated and stereotypical portrayal of extremist religiosity.