This dissertation illustrates the development and realization of a conceptual tool for the integrated multilevel analysis of regional resilience. “Resilience” here describes the capacity of a System to absorb shocks without collapsing. The concept of resilience has been embraced by many scientific fields in recent years, yet surprisingly little is known about the extent to which the resilience theory can be applied to spatial development. Consequently, the goal of this research is to ascertain how regional resilience works, how to manage, monitor and evaluate resilience processes in a specific region. Utilizing theories on social-ecological systems and planning, the research project developed a framework for the multilevel analysis of regional resilience, which was applied in a transdisciplinary case study in a region in the southeast of Austria. Specifically, a situation analysis of the region, focusing on ecosystem services, was undertaken, followed by a study of regional change dynamics and an evaluation of the governance structure. The findings have been integrated into regional planning scenarios that are the foundation for resilience-based policy recommendations. Regions do not simply “generate” their own resilience they are also affected by higher governmental strategies for sustainable development. Therefore, this study employs the resilience framework to harmonize those strategies between the different territorial levels.