This Thesis analyses the consequences of climate change for the sector "Manufacturing and Trade", an important field of the Austrian National Adaptation Strategy. The productivity losses of workers due to changing working conditions are evaluated quantitatively. The Wet Bulb Globe Temperature-index, a heat strain index for workers combining information on temperature and relative humidity is used to calculate the productivity losses. The Human Capital Approach converts these productivity losses in monetary terms using the hourly wage of workers as costs of lost working hours. In order to calculate spillover and macroeconomic effects a Computable General Equilibrium Model is used. Using an extensive literature review focusing on national and international projects the following impact chains are analysed qualitatively: Stability of production processes, changes in cooling and heating demand, effects on the supply chain, changes of private consumption and damages to internal and external infrastructure.Quantifying the impacts of productivity loss due to climate change we find the following: In the mid-range climate scenario in the 2050s, GDP and welfare decrease by ? 65 and ? 39 million and the Austrian government budget by ? 13.6 million. In the high-range climate scenario, GDP and welfare decrease by ? 241 and ? 169 million and government budget by ? 53.9 million.The impacts on ?Manufacturing and Trade?, investigated qualitatively in this Thesis, are extremely branch-specific, depending on demand and supply interlinkages from and to other vulnerable sectors, energy-intensities, production processes and changing consumer preferences. The approach used in this Thesis shows various uncertainties. Although further research is necessary, this Thesis clearly points out that it is important to consider certain effects. Furthermore, it is necessary to develop methods to quantify the effects that are only discussed qualitatively in this Thesis.