This thesis deals with the impacts of the road, from Beni into the Kali Gandaki valley to Jomsom and further to Muktinath, Nepal, on the social structures, settlements and tourism in that region. The main research question is how the road development does have impacts on the daily life of the local population. Beside the physical threats through landslides and dust, the focus lies on the economic impacts. Trekking tourism has played a decisive role in generating great income as the region is home to the world-famous Annapurna Circuit Trek. The road construction affects this tourism sector in a crucial manner. On the other side, the famous pilgrimage site of Muktinath which is the highest settlement of the research area, receives masses of pilgrims since the temple site is reachable by Jeep. In this aspect, the transformation of these tourism structures is pointed out in detail. A research stay in Nepal has been undertaken to observe the impacts on site. Numerous key informant and stakeholder interviews with the local population, representatives of the tourism industry and tourists have been conducted. Based on the four pillars of sustainability, the results of the field survey have been classified into ecological, economic, social as well as institutional impacts. Which groups of the population benefit from the present development and which suffer from it was a further research question which has been revealed during the field survey. Furthermore, the development of the road construction in the Kali Gandaki valley up to Upper Mustang is still going on - opening up new challenges of managing these developments in a way to sustain the unique natural beauty of the region while strengthens its communities and their tradition.