This study investigates the effects of depression and mental activation of social support (providing and receiving social support, neutral condition) on cardiovascular reactivity during a social stressor. The activated support schemas were, thinking to receive or provide social support and a neutral condition. For the first time, this study investigates the effects of providing social support in depressive individuals. A number of studies showed a stress-buffering effect of social support on cardiovascular reactivity. However, some studies suggest, that social support has a negative effect in depressed persons. Sixty healthy female students between the age of 18 and 30, which have been divided into groups with high and low depression, were tested. The social stressor consisted of holding a speech in front of a video camera. Before this speech, there was a stressor anticipation period and a period to prepare the following speech. In all periods the cardiovascular parameters (systolic blood pressure, diastolic blood pressure and heart rate) were elevated and compared to baseline. Furthermore, the subjective well-being, cognitive task appraisal, rumination and other psychological parameter were tested. The results showed, that there were no differences on cardiovascular reactivity in high and low depressed individuals during the task periods. Generally, females high in depression showed greater increases in systolic blood pressure, than lower depressed females. Social support had no effects on cardiovascular reactivity, subjective well-being, cognitive task appraisals or rumination. On the other hand, before and after the speech task, high depressive females showed more negative cognitive task appraisals than low depressive females. During the recovery period, high depressed females showed more negative rumination. Further, females high in depression reported more interpersonal stress and lower perceived social support.