This is about the phenomenon of mental-health problems of art historians. The academic achievements of art historians, whose illnesses and life-crisis are proven, will be presented and connected to their historical research in arts.Based on Warburg a connection will be made to other academics, who suffered, all in a different way and for diverse reasons, from mental health problems and inner conflicts due to their academic work. The synopsis shall illustrate the common ground between these scientists, especially how they influenced the subject. Starting point is the theory that those scientists were mostly pioneers, outriders and forerunners within their academic field and that their innovative ideas weren`t understood by their contemporaries. Incomprehension and missing sympathy could have triggered the emotional retreat of the researchers into their own world.To proof this theory, the art historians will be presented under the following aspects, which were crucial for their crises: the handling with the definition of renaissance and genius, the recourse to interdisciplinary projections, the use of a very personal, academic language, experiences with escape and emigration as well as the engagement with the "primitive human being" and his relation to arts. Finally it is interesting to see that most of these mentioned aspects also apply to Warburg, which is why he was such an innovative but also endangered person.