AbstractCreativity has always been an interesting and challenging topic in our society. But (neuro-) scientific research on this topic is rare. The aim of the present study was to investigate the relationship between creativity, measured with four psychometric tests for the assessment of different facets of verbal and figural creativity, and grey matter volume, as quantified by means of voxel based morphometry. 71 healthy, right-handed subjects participated in our study. In order to control for potential influences of age, intelligence and sex on our results, we included these three variables as covariates in statistical analyses. Based on previous studies, we hypothesized positive associations between creativity and grey matter volume in regions of the right prefrontal cortex, the Precuneus and the Insula. Our results revealed a significant positive correlation between grey matter volume and creativity in the Precuneus and Cuneus, regions which play an important role in visual imagination. Additionally negative correlations were observed in a network involving brain regions such as the putamen, the insula and the superior frontal gyrus. Putamen and insula are known to be involved in language production, whereas the right frontal lobe is believed to play a role in generating unusual, verbal associations. It is still unclear up to the present, whether more or less grey matter volume is related to higher creativity. Taken together, this study revealed a pattern of results according to which more grey matter volume in posterior and less grey matter volume in frontal brain regions are associated with higher creativity, as measured by means of divergent thinking tasks.