In the realm of health trade professions, dental technicians occupy a key position between craftsmanship and medicine. Their work encompasses the manufacturing of dentures as well as orthodontic appliances and epitheses. With regard to medical device legislation, it centers on creating custom-made medical appliances, which earns dental technicians an integral role in the health care system. There are, however, no current comprehensive and, especially, no comparative studies on their work and legal duties as special manufacturers of medical appliances in Germany and Austria, particularly in terms of the legal examination of custom-made medical appliances as a specific category of medical products. Due to a growing individualization of medical devices, custom-made medical appliances gain in importance and are thus subject to distinct legal regulations. This paper is to first provide an outline of the requirements concerning dental technicians and their vocational training, further training and exercise of profession in Germany and Austria with respect to medical device legislation. Second, the legal situation of custom-made medical appliances will be discussed from the perspective of dental technicians with their experience in producing the devices. Significant questions regarding dental technicians as manufacturers of medical devices, the classification of dental products as custom-made medical appliances and their placing on the market will also be reviewed from a legal point of view. Finally, the most important legal duties a dental technician has to attend to after placing a product on the market will be examined. All of the above will be put into the context of a German-Austrian comparison.