The study's main focus lies on the rise and fall of paper manufacturing in Basle and in how far the industry's general technical progress was taken into consideration by the local proponents and used for their manufacturing processes. For this purpose, the technical achievements and innovations made between the 15th and 19th century will be looked at, together with the new raw materials that these entailed. As pertains to the city of Basle, the paper will examine those inner and outer influences that made an impact on paper manufacturing and look at how it furthered or hindered the local industry. Amongst those are not only the Council of Basle, the foundation of Basle University and the subsequently flourishing printing industry, but also the trade guilds, the City's endowment with the privilege for annual fairs and finally, by way of example, the influencing role of the families chiefly engaged in paper manufacturing. The results clearly show the lasting influence of the guilds on the paper manufacturers, chief among them the Safranzunft. Through their rigorous adherence to old patterns of the manufacturing and the oath "never to let the old slip nor the new enter", they may have ensured equal chances among all the artisans, but at the same time thoroughly prevented any innovations entering the manufacturing halls. Foreign competitors, the constricted topography of the city's quarter wherein lay the Basle paper mills as well as the individual fates of the local paper manufacturing families all added to the slow but certain demise of the paper manufacturing industry.