Every year about 500 000 people die from colo- and rectalcancer all over the world. It is possible to provide good healing and survival chances through surgery. Especially, possibilities of treatment such as additional chemo- or preoperative radiotherapy play an important role and lead to an extensive improvement of symptoms.During a tumor disease impairments of the mental state can occur. Hence, in the field of Oncology research in Quality of Life (QoL) plays a significant role. Further, in the field of healthcare provision, research of life quality has an increasing impact. The aim of the present study is to examine, if there are differences between male and female patients with stoma and patients without stoma in regard to overall QoL and meaning in life. Therefor, 20 patients with and 20 patients without stoma were testet.Although the initial cancer diagnosis was made about four years earlier, stoma-patients only show minimal deficits in role functioning as well as in specific symptoms such as pain, dyspnea and obstipation, which usually persist over years. Regarding overall QoL, there are no significant differences between stoma patients and patients without stoma, neither between men and women. Also, in regard to existential meaning stoma patients show no different reactions compared to patients without stoma. Again, the comparison between men and women does not show any significant difference too. The regression analysis shows that the variable ?phobic anxiety? provides a valuable contribution to predict the overall QoL, as higher phobic anxiety leads to lower QoL. The variables ?obsessiveness?, ?somatization? and subjevtive disgust-sensitvity contribute to a prediction of existential meaning, as higher scores in these variables lead to lower existential meaning.