The lateralization of different functions in the human brain represents a longstanding proven fact. Usually, it is the left cerebral hemisphere, which is seen as the dominant one for language. But since more than 100 years there are also known cases, which demonstrate the dextral lateralization of language. Scientists still work on this topic and try to find the correlations between cerebral dominance for language, praxis and handedness. Main topic of this work is the crossed aphasia, which represents an example for an atypical cerebral lateralization of functional processes in the brain. In the present case crossed aphasia is even connected with buccofacial apraxia. After a short approach to the psycholinguistic foundations as the structure of the human brain, lateralization and different forms of aphasia, the main work refers to crossed aphasia. This term characterises aphasic syndromes after a right-hemispheric brain damage in right handers. An additional introduction to the different forms of apraxia and the connections of language, praxis and handedness offers the transition to the applied materials for diagnosis and therapy ? LEMO and MODAK. The present case study describes in detail the individual symptomatology in a case of crossed aphasia with buccofacial apraxia. The individual analysis of this case is the foundation for the following discussion, in which similar cases of the literature are compared to the present pattern of disorders. Hereby, the problems of diagnosis and the difficulties concerning the comparability of such cases are discussed as well. By means of the available data an interpretation takes place with respect to the previous hypotheses in terms of language, praxis and handedness as well as in terms of the diagnosis of crossed aphasia. Hence this case study delivers another contribution to the investigation of crossed aphasia in connection to apraxia.