Solvent-free melting techniques allow for fast and cost-effective processing by omitting process steps such as solvent evaporation and recovery. This technique is often applied for manufacturing controlled release formulations or used for taste masking, while the absence of solvents makes it suitable for drugs sensitive to hydrolysis. Triglycerides are particularly well suited coating materials. As part of our everyday diet, triglycerides arerecognized as toxicologically harmless natural products and are significantly cheaper than the polymers used in solvent-based processing. However, major drawbacks are thelimited applicability to heat-sensitive drugs and storage instabilities due to uncontrolled polymorphic, micro- or macrostructural changes. Nevertheless, we were able to mask the taste of the thermosensitive drug N-acetylcysteine with a solvent-free coating comprising tripalmitin and polysorbate 65 without impairing the immediate drug release profile. The O/W emulsifier polysorbate 65 accelerates both the drug release through the hydrophobic lipid coating and the transformation at low process temperatures. Although this formulation exhibited the stable polymorphic -form and met the required storage stability, studies with pure tristearin coatings showed significant discrepancies in the dissolution of differently manufactured formulations comprising the stable -polymorph. Hence, future formulation development with lipid-based substances will not only require a closer examination of the polymorphism, but also a deeper understanding of the micro- and macrostructure, both of which are influenced by the applied manufacturing technique and storage conditions.